Nanofeaturing Materials for Specific Cell Responses
Abstract
A review of the ways in which cells react to nanofeatured surfaces is given. One of the prime reactions is of adhesion or otherwise to such surfaces. Topography appears to be of considerable importance and a wide range of cell properties are affected by the type, scale and regularity of topography. Chemistry can be combined with topography to fine- tune effects Mechanical forces are also of importance but in practice it is hard to control these. Examples will be given of methods of controlling adhesion, morphology, orientation, movement, phagocytic activity and activation and gene expression of cells. Effects vary according cell type and also the spacing and size of nanofeatures. A discussion of the application of these findings to the medical devices conclude this short review.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2005
- Accession Number
- ADP019718
Entities
People
- Adam Curtis
Organizations
- University of Glasgow