Selective Laser Sintering of Polycaprolactone Bone Tissue Engineering Scaffolds

Abstract

Present tissue engineering practice requires porous, bioresorbable scaffolds to serve as temporary 3D templates to guide cell attachment, differentiation, and proliferation. Recent research suggests that scaffold material and internal architecture significantly influence regenerate tissue structure and function. However, lack of versatile biomaterials processing methods have slowed progress towards fully testing these findings. Our research investigates using selective laser sintering (SLS) to fabricate bone tissue engineering scaffolds. Using SLS, we have fabricated polycaprolactone (PCL) and polycaprolactone/tri-calcium phosphate composite scaffolds. We report on scaffold design and fabrication, mechanical property measurements, and structural characterization via optical microscopy and micro-computed tomography.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2005
Accession Number
ADP019721

Entities

People

  • Brock Partee
  • Scott J. Hollister
  • Suman Das

Organizations

  • University of Michigan

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Computational Science
  • Engineering
  • Geometry
  • Health Services
  • Materials
  • Materials Engineering
  • Materials Processing
  • Materials Science
  • Mechanical Properties
  • Mechanical Working
  • Medical Personnel
  • Selective Laser Sintering
  • Sintering
  • Surgery
  • Three Dimensional
  • Tissue Engineering
  • Transplants

Fields of Study

  • Materials science

Readers

  • Immunology and Pathology
  • Reinforced Composite Materials
  • Software Engineering.

Technology Areas

  • Directed Energy