HIV Medical Development
Abstract
The Military Human Immunodeficiency Virus (HIV) Research Program develops vaccine candidates, to assess their safety and effectiveness in human subjects, and to protect military personnel from risks associated with HIV infection. All HIV technology development is conducted in compliance with United States Food and Drug Administration (FDA) regulations. This program is jointly managed through an Interagency Agreement between the United States Army Medical Research and Development Command (USAMRDC) and the National Institute of Allergy and Infectious Diseases. The cited work is also consistent with the Assistant Secretary of Defense, Research and Engineering Science and Technology focus areas. The Walter Reed Army Institute of Research (WRAIR) Vaccine Pilot Bioproduction Facility (PBF) is the Department of Defense (DOD) only facility capable of producing good manufacturing practices (GMP) quality biologic products for use in early phase clinical trials. The mission of the WRAIR PBF is to support the development and licensure of vaccines and relevant biologics critical to the global health of our Warfighters serving domestically or abroad in compliance with United States FDA regulations. This project supports vaccine development efforts of strategic importance to the DoD, including Service medical research and development programs, those of other DoD organization such as the Defense Threat Reduction Agency and the Defense Advanced Research Projects Agency, and pandemic bio preparedness for emerging infectious disease threats in the Global Health Security Agenda. The Underbody Blast (UBB) Testing medical research project will provide new data on the biomechanics of human skeletal response that occurs in an attack on a ground combat vehicle, it will provide better protection to mounted warriors from the effects of underbody blast caused by landmines or improvised explosive devices (IEDs). The data will provide a biomedical basis for the development of a Warrior-representative blast test manikin (the Warrior Injury Assessment Manikin or WIAMan project) and the required biomedically-valid injury criteria that can be used in Title 10 Live Fire Test and Evaluation (LFT&E) to characterize dynamic events, the risk of injury to mounted warriors, and to support acquisition decisions. The data produced by this project will be used to satisfy a critical need for a scientifically valid capability for analyzing the risk of injury caused by UBB. The Deployed Warfighter Protection project, the Armed Forces Pest Management Board (AFPMB), plans to develop new or improved protection for ground forces from disease-carrying insects. The focus of this program is to develop new or improved systems for controlling insects that transmit malaria, dengue, chikungunya and other emerging infectious diseases under austere, remote, and combat conditions; understand the physiology of insecticidal activity to develop new compounds with greater specific activity and/or higher user acceptability; examine existing area repellents for efficacy and develop new spatially effective repellent systems useful in military situations; develop new methods or formulations for treating cloth to prevent vector biting; and expand the number of active ingredients and formulations of public health pest pesticides, products and application technologies available for safe, and effective applications. The AFPMB partners with the President's Malaria Initiative and the World Health Organization Global Malaria Program to lead development of new tools for insect-borne disease prevention. The Medical Operational Data System (MODS) deploys modernized data visualization capabilities to enhance Army Unit and Individual Medical Readiness Reporting. MODS provides Army leadership with a responsive and reliable human resource and readiness information management data system for all categories of military and civilian medical and support personnel. MODS provide Tri-Service support through applications such as Electronic Profile, Behavioral Health, and Medical Education. The Pharmacovigilance Defense Application System (PVDAS) provides military providers Defense Patient Safety reports from the Food and Drug Administration (FDA) after a drug's release to market. The program identifies, explores, and demonstrates key information technologies to overcome medical and military unique technology barriers. The Mobile HealthCare Environment (MHCE) is the capability of secure, bidirectional messaging and data exchange between patients, providers and clinics using any electronic device. The program identifies, explores, and demonstrates key information technologies to overcome medical and military unique technology barriers. The Civilian Authorized Salaries and Other Operational requirements provide funding for authorized civilian workforce performing medical research, development, acquisition management and oversight that support the medical research, development, test, and evaluation (RDTE) programs at the United States Army Medical Research and Development Command (USAMRDC), Fort Detrick, Maryland.
Document Details
- Document Type
- Project
- Publication Date
- Oct 01, 2022
- Source ID
- EB3_0603115A_3_2040_PB_2022
Related Documents
- Root: Medical Development
- Child Accomplishment: HIV Medical Development
- Child Accomplishment: WRAIR Vaccine Production Facility Research
- Child Accomplishment: Underbody Blast Testing
- Child Accomplishment: Deployed Warfighter Protection
- Child Accomplishment: Medical Operational Data System
- Child Accomplishment: Pharmacovigilance Defense Application System
- Child Accomplishment: Mobile Health Care Environment
- Child Accomplishment: Civilian Authorized Salaries and Other Operational Requirements