Ascertaining The Importance of fluorescent Sensors in Detecting Hypoxia Tolerance at High Altitude
Abstract
Air crews are prone to exposed to high altitude which, has higher potentially dangerous maneuver with serious health risk. The episode of prolong exposure to high altitude can cause hypoxia that include of permanent neurological damage that may result in a subject being subsequently unfit for training. In people with the high altitude disorder, the body's reaction to high altitudes starts with the formation of a protein called hypoxia-inducible factor (HIF), which triggers a series of other physiological changes and plays a central role in the hypoxia response; its activity is regulated by the oxygen-dependent degradation of the HIF-1? protein (HIF-1A gene). This deserving condition provides an opportunity to study the effects of low oxygen tension of prolonging in high altitude that could lead to hypoxia using fluorescent sensors of hypoxia. The 40 subjects of fits individuals will be recruited from the Institute of aviation medicine, Royal Malaysian Air forces. The air crews will divide into two group which is the first group as a control group of 20 subjects that will placed at the sea level and second group of 20 subjects will placed at level of 10,000 feet’s altitude of routine flight duration of 8 hours. Both group will undergo fluorescent sensors of hypoxia test to measure the changes of biomarker of HIF-1? protein with measurement of pulse, blood pressure, temperature, and oxygen saturation monitor (fingertips pulse oximeter). For the 2nd group, the fluorescent sensors of hypoxia test will be measured immediately before and after 8 hours of flight along with the cognitive assessment to assess the cognitive performance. Nonetheless, there were yet any substantial data that determine the feasibility of the fluorescent sensors of hypoxia test to detect the changes of biomarker of HIF-1? protein that can be used as a surrogate diagnostic tools in detecting hypoxia.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 21, 2022
- Source ID
- FA23862114007XX0
Entities
People
- Shazreen Shaharuddin
Organizations
- Air Force Office of Scientific Research
- National Defence University of Malaysia
- United States Air Force