Utilizing model systems to investigate the molecular underpinnings of cellular adaptations in microgravity.
Abstract
The Earth’s gravitational field is an omnipresent force that has shaped the form and function of Earth-based biology. It is possible for Earth based organisms to survive for sustained periods in low gravity environments, however extended exposure to such conditions is known to result in significant alterations in biological function. There are significant gaps in knowledge regarding the mechanistic underpinnings of these changes that require the development of new model systems and extensive ground based studies that allow testing of a broad set of parameters. This project will therefore use simulated microgravity in ground-based studies to circumvent the limitations of accessing real microgravity. The simulated microgravity will be applied to two distinct, simple model systems (Red blood cells (RBCs) and Schizosaccharomyces pombe) to enable interrogation of the role of different types of structural molecules and force sensors in cellular adaptations to reductions in gravitational loading. The outcomes of this work will be increased insight into the impact of microgravity at the cellular level and the molecular players that mediate these changes.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Feb 16, 2024
- Source ID
- FA23862314045
Entities
People
- Kate Poole
Organizations
- Air Force Office of Scientific Research
- United States Air Force
- University of New South Wales