Specifying the Global-Seasonal Ionospheric Density Variation and its Space Weather Effects for Assessment of Space Communication
Abstract
Dopamine (DA), serotonin, cortisol, ascorbic acid (AA), uric acid (UA), glucose, and fructose are some of the important neurotransmitters and essential bio-molecules that play a fundamental role in the function of the central nervous, renal, hormonal, and cardiovascular systems. Quantitative analysis of these bio-analytes using biosensors has shown great promise in medical diagnosis and early disease management. The surface of the biosensors is mounted with suitable bioreceptors for efficient detection of these bio-analytes. Especially, a bioreceptor s sensing characteristics to its target make it so useful as a diagnostic tool for the disease. Through this proposed work, highly selective and sensitive ultra-short peptides towards the neurotransmitters and other essential bio-analytes will be designed and developed. Suitable density functional theory (DFT) codes will be employed for the modelling and computations. Initially, various amino acids of different chemical nature will be fused to produce 3 to 5 units adorned USPs. Their physico-chemical, electronic and optical properties will be investigated. Meanwhile, the essential neurotransmitters and other bio-analytes will be modelled and their properties will be studied similar to USPs. Further, the optimized USPs will be made to interact with the target analytes in solvent phase. The magnitude of interaction will be understood through interaction energy calculations, HOMO-LUMO changes, charge transfer, change in dipole moment. Then, sensing parameters like sensitivity, selectivity, response time will be calculated to understand discriminant sensing performance of USPs. In summary, in-silico engineering of USPs are powerful, fast and cost effective for rapidly identifying the best USPs that can detect the target neurotransmitters and other bio-analytes. Finally, as a proof-of-concept, electrochemical biosensors based on highly selective and sensitive USPs will be fabricated and tested towards target neurotransmitters and other essential bio-analytes.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Feb 05, 2025
- Source ID
- FA23862414010
Entities
People
- Lung-chih Tsai
Organizations
- Air Force Office of Scientific Research
- National Central University
- United States Air Force