Nanopore Formation in Lipid Bilayers: Insights from Mechanochemical Models
Abstract
The objectives in this work will be to investigate (a) the role of lipid orientation and rearrangement during the formation of nanopores, and (b) the impact of nanopore formation in biochemical signaling in neurons. This will require new mathematical models to explain the mechanics and energetics of nanopore formation and predict the rearrangement of lipids in the membrane. These models will then be used to investigate the interaction between pore formation and calcium-mediated signaling in neurons.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 23, 2016
- Source ID
- FA95501510124
Entities
People
- Padmini Rangamani
Organizations
- Air Force Office of Scientific Research
- United States Air Force
- University of California, San Diego