Understanding the Bioelectric Aspects of Cytoskeletal Dynamics
Abstract
The objective of the proposal is to query and understand the internal communication and movement capabilities within living cells and tissues. The PI intends to manufacture nanoscale silicon materials that have been shown to be compatible within the cells. Following this he will grow semiconductor heterostructures along with microscopy techniquest to study structural changes and movements within living cells. Following this manufacturing process he will take the developed nanowire cross-bar array to study the bioelectric signal of the motor protein/microtubule interactions in vitro. They intend to electrically stimulate the motor protein dynamics ie. change of speed, direction and response time. The PI will use silicon nanoscale photodiodes as wireless cytoskeletal stimulators inside cells to determine the effects in the intracellular transport, cell shape and focal adnesion dynamics if any. These techniques are required to study the internal milleau and movement of the specific cells and their organelles. We intend to understand how communication takes place inside the cell and how structures move around and transport their product.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 23, 2016
- Source ID
- FA95501510285
Entities
People
- Bozhi Tian
Organizations
- Air Force Office of Scientific Research
- United States Air Force
- University of Chicago