Single-Molecule Bioelectronic Devices With Multi-Sensing Capability
Abstract
Current strategies for the fabrication of bio-sensing devices do not allow for combined ultrahigh sensitivity, low-cost processability, and simultaneous detection of multiple biotargets. Advances in micro/nanofabrication technologies and the discovery of abundant nanoscale materials, have now opened up new possibilities for developing novel bioelectronic sensors with the aforementioned characteristics, which hold great potential for applications in a wide variety of areas, ranging from diagnosis of life-threatening diseases to detection of biological agents in warfare or terrorist attacks.The primary goal of this project is to develop a new generation of bio-sensing platforms based on single-molecule bioelectronic interfaces, that will allow the simultaneous detection of several types of biotargets on a single biochip. We will achieve this applying novel methods to interface individual proteins to carbon nanoelectrodes in solution, and subsequently organizing the so formed molecular junctions on surfaces for device implementation. As proof of concept we will target (in parallel) biomarkers associated with stress, toxicity, injury and disease progression.The relevance and impact of the expected outputs will include: i) improved analysis of biological and chemical agents with single-molecule resolution; ii) novel platforms for the low-cost fabrication of miniaturized multipurpose biosensing devices, that thanks to their intrinsic biocompatibility and flexibility hold great potential as wearable and implantable body nano-sensors.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Dec 05, 2016
- Source ID
- FA95501610345
Entities
People
- Matteo Palma
Organizations
- Air Force Office of Scientific Research
- Queen Mary University of London
- United States Air Force