Understanding the multidirectional axes of communication between the gut microbiome and the brain to augment human performance
Abstract
Firstly, establish a local microbial and host metabolite signature with a high temporal resolution following acute restraint stress. Subsequently, gain mechanistic insights, focusing on the role of intestinal permeability as a route to impairment at the level of the central nervous system. Define the relevance of these dynamic host-microbe interactions for cognitive performance and explore the fate of the identified alterations in the microbiome-gut-brain axis following repeated exposure to restraint stress. Taken together, these studies will inform future strategies aimed at targeting the gut microbiome to promote stress resilience and optimize human performance in stressful environments.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Feb 06, 2017
- Source ID
- FA95501710016
Entities
People
- John F. Cryan
Organizations
- Air Force Office of Scientific Research
- United States Air Force
- University College Cork