Elucidating the cellular and sub-cellular dynamics during electromagnetic modulation of the nervous system
Abstract
The primary objective of this proposal then is to unravel the interplay between neurobiological signaling, electric nerve conduction and the thermal gradient induced by electromagnetic radiation in the form of light using theoretical as well as experimental approaches. We will obtain insight into inhibiting neural systems in unmyelinated as well as myelinated models to effectively use this approach for improve care and increased performance in humans. Further, we will modify our theoretical model for more complex processes associated with inducing i.e. stimulating neural activity. We will conduct experiments to image the active processes that occur when light interacts with the nervous system. The goal of this research then is to identify the cellular and sub-cellular components that cause the excitatory and inhibitory responses of a neural cell to optical perturbation and to model the effect of the various optical parameters on the bio-electric phenomenon that is observed in the complex neural system at the at the atomic level. To achieve these objectives, the following two specific aims are proposed.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Sep 11, 2017
- Source ID
- FA95501710374
Entities
People
- Anita Mahadevan-Jansen
Organizations
- Air Force Office of Scientific Research
- United States Air Force
- Vanderbilt University