Evaluating high resolution in vivo proton imaging at nanoscale
Abstract
Microscopy has been an integral part of scientific development. Miniaturization hasspurred further development in many fields. But currently optical microscopy is limited by thediffraction effect due to the wavelength of light. Charged particle beams are promising probes toobtain nanoscale resolution attributing to the practical absence of diffraction effect. A pioneerexperiment which imaged living cells using electron beam induced fluorescence has beendemonstrated . However an electron beam very quickly losses its resolution when penetratingcells. In contrast, microscopy using fast protons has several advantages over other forms ofmicroscopy. Proposed here is a fast incoming proton mainly interacts with electrons in materials. Due to the mass mismatch between protons and electrons a proton beam practically follows a straight path through material and tissue.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Apr 09, 2018
- Source ID
- FA95501810110
Entities
People
- Jeroen Van Kan
Organizations
- Air Force Office of Scientific Research
- National University of Singapore
- United States Air Force