Three dimensional brain in vitro models via electrofluidodynamics
Abstract
3DNEUROGLIA is a proposal for a project with two Italian teams (CNR IPCB and CNR-ISOF)with the aim to identify efficient in vitro 3D model to study neural cells functions and biophysicalmechanisms underpinning brain activity in physiological context as well as upon chemo-physicalstimuli. 3DNEUROGLIA will optimize different tailored micro/nanostructured material platformsto provide an efficient in vitro 3D model where to study at multi spatial and time scale biophysicalmechanisms underpinning neural cells functions and interaction, in a controlled and reliablephysiological context and upon physical stimuli such as photo-stimulation. 3DNEUROGLIA modelwill be defined and validated to enable an approach for studying brain physiology and its modulation by bioelectronic/biophotonic stimulation at a multiscale from nano- to micro-domainsof the cell (i.e., cell membrane, ion channels/water channels, protein complex on cells endfeed/synapse), up to cellular level; the dynamics occurring at the macroscale (network scale,microcircuits, tissue scale) will be identified and characterized by co-culture of neurons and glialcells.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 28, 2018
- Source ID
- FA95501810255
Entities
People
- Vincenzo Guarino
Organizations
- Air Force Office of Scientific Research
- Consiglio Nazionale delle Ricerche
- United States Air Force