Modulating Cellular Performance with Nanoscale Biocircuits
Abstract
The performance of organisms finds its origins in the function of and interaction between cells.1–3 Understanding signaling within a single cell as well as signaling between two or more cells is fundamentally central to the function and behavior of cellular systems, and the overall performance of an organism.4–8 Well studied processes, including the firing of neurons (calcium ions),9 neurotransmission linked to brain activity (serotonin and dopamine),9 and cellular energy transduction and apoptosis (ATP, oxygen, reactive oxygen species),10,11 illustrate the intimate link between function and behavior of an organism as a whole. Further understanding of such stimuli behavior connections raises the opportunity to leverage these stimuli to control cellular signaling and hence manipulate biological function from the level of a single cell and cellular networks to ultimately tissues, organs, and the organism.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 14, 2022
- Source ID
- FA95501910246
Entities
People
- Dan Nocera
Organizations
- Air Force Office of Scientific Research
- President and Fellows of Harvard College
- United States Air Force