DEVELOPMENT AND TESTING OF NOVEL MINIMALLY INVASIVE ACUITY INDEXES FOR PROLONGED FIELD CARE IN TRAUMA PATIENTS
Abstract
In this proposal we will test 4 new medical diagnostic devices developed at the Beckman Laser Institute at University of California Irvine (BLI/UCI). These sophisticated technologies were designed to diagnose respiratory failure, monitor metabolic process in the body to assess extent of injury and detect bleeding/clotting disturbances in the blood. BLI/UCI is developing prototypes of these devices that are optimized and miniaturized for use in trauma and patient care in the field -- outside of the hospital. Specifically, these devices could be beneficial for the military during field care of combat wounded. In the proposed study we will evaluate these new technologies using an animal model that simulates battlefield injuries such as 1) lung failure/acute respiratory distress syndrome (ARDS) caused by smoke inhalation and burns and 2) significant blood loss/hemorrhage. The work aims to: (i) validate the accuracy of a novel monitor placed under the skin that continuously measures metabolic waste products and levels of oxygen/carbon dioxide in the blood; (ii) evaluate a sensor that detects blood oxygenation over the skin and compare to standard laboratory measurements; (iii) validate a new laser-based clinical imaging system to take high-resolution images of the lining of the lungs that could previously only be observed under a microscope; and 4) monitor clot formation in real-time in a blood sample without using bulky, sensitive laboratory instruments. We anticipate that these mobile, miniaturized devices will provide accurate information when compared to established laboratory tests that are available only in hospital laboratories using large, cumbersome instruments. We posit that these technologies will provide accurate, reliable information to diagnose critical conditions in the field following combatrelevant injury and will give clinicians useful information to guide treatment decisions before the patient is admitted to the hospital.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 12, 2021
- Source ID
- FA95502010065
Entities
People
- Andriy I. Batchinsky
Organizations
- Air Force Office of Scientific Research
- Geneva Foundation
- Office of the Secretary of Defense