OPTICAL MODULATION OF CELL REDOX STATE
Abstract
Short pulses of infrared laser light provide a label-free, non-contact method to induce or inhibit action potentials in neurons. However, these opposing effects cannot yet be fully explained mechanistically. Electrical activity of neurons is closely linked with cellular metabolism and the redox state (ratio of reduced and oxidized species) of the cell as energy is required for channel activation to pump ions across concentration and voltage gradients. Furthermore, NAD(P)H, a metabolic coenzyme and electron donor, regulates ion channel activity directly through interactions with voltage gated sodium and potassium channels. Therefore, this proposal will test the hypothesis that pulsed infrared light modulates the electrical activity of cells by altering the redox state of the cell.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 12, 2021
- Source ID
- FA95502010078
Entities
People
- Alexandra Walsh
Organizations
- Air Force Office of Scientific Research
- Texas A&M University
- United States Air Force