(YIP)MULTISCALE ELECTRICAL MAPPING OF BIOSYSTEMS
Abstract
The ultimate goal of this program is a bioelectronic platform technology for mapping the physicochemical signals of a whole tissue-scale biosystem over long periods of time at micrometer-submillisecond resolution without trade-off in sensitivity. Implementation of the technology will pave the way to building scientific understanding of dynamic and collective behaviors of large-scale cellular systems and bridge cellular electrophysiological and microenvironmental-chemical activities to tissue behaviors. Since the transducers to be developed in the technology are suited to be used as actuators as well, the impact of the technology can extend to brain-machine interface, human performance enhancement, and biological control. The program represents the innovative application of a self-driven Faradaic current that is unique to two-dimensional materials (TDMs) to interface biosystems and uncover unknown phenomena in biophysics and address high-impact problems. This strategy can deliver outstanding compatibility of the TDM-based bioelectronics with the high-throughput high-performance microelectronics in size, device density, and capacity, which overcomes the major challenge for electrically interfacing large-area tissue at cellular level. In this program, we will use systematic approaches to engineer TDMs for the optimal level of self-driven current, fabricate TDM microelectrode arrays (MEAs) with device feature size comparable to single cells, and build a platform system based on the TDM MEAs to map both action potential and microenvironmental concentration of neuropeptides in electrogenic cellular systems. We will use the platform system to investigate the association between ghrelin, neuropeptide secretion, and synaptic plasticity, in a cultured neuron system.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 12, 2021
- Source ID
- FA95502010125
Entities
People
- Jinglei Ping
Organizations
- Air Force Office of Scientific Research
- United States Air Force
- University of Massachusetts