Macromolecular Modeling of Biomimetic Assembly
Abstract
We propose to perform statistical mechanics based polymer theory and multiscale molecular modeling on four major areas: (1) New paradigm of macromolecular recognition, complexation, and assembly, (2) Biomolecular condensates and coacervate phase transition, (3) Regulated gelation and structured hydrogels, and (4) Mucus: Assembly kinetics, structure, and volume transition. The conceptual framework to be generated from the proposed research will be general and applicable to a vast set of biomolecular assemblies constituting membrane-less organelles as well as to make a fundamental understanding of mucus and their mimics. The proposed work is complementary to the ongoing e orts in the current program and many other laboratories worldwide. Our proposal builds on various fundamental concepts from polymer physics, which are pragmatically suited to successfully address the rich phenomenology of biological and biomimetic assemblies. Our work will be conducted in synergistic cooperation between us and several experimental groups. In addition, we will continue to provide support to the program participants with our static and dynamic light scattering expertise as well as theoretical/modeling expertise.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 12, 2021
- Source ID
- FA95502010142
Entities
People
- Murugappan Muthukumar
Organizations
- Air Force Office of Scientific Research
- United States Air Force
- University of Massachusetts