DEVELOPMENT OF DUAL WAVELENGTH RAMAN SPECTROSCOPY AND ITS APPLICATION FOR HYDRATION ASSESSMENT
Abstract
Raman spectroscopy is a promising optical modality for the non-destructive determination of material or tissue biochemical composition, including water quantification. Here we propose the development of a dual region approach, combining the biochemical specificity of the “fingerprint region” with the hydration information provided by the “high wavenumber” region. The resulting instrumentation will be capable of collecting Raman signal from varying depths in both synthetic and biological samples, including plastic, cement, soil, and in vivo human tissues. This system may be used as a tool for rapid quantification of systemic hydration levels in humans, an area of critical need for military personnel who are especially susceptible to dehydration, and a portion of our efforts will be directed towards optimizing Raman spectroscopy for this application. It is hypothesized that Dual Region Spatially Offset Raman Spectroscopy (DR-SORS) will permit precise depth dependent quantification of biochemical content including water in materials and tissues.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 12, 2021
- Source ID
- FA95502010225
Entities
People
- Anita Mahadevan-Jansen
Organizations
- Air Force Office of Scientific Research
- United States Air Force
- Vanderbilt University