Coping with environmental stress: at the interphase between neuronal proteostasis and brain physiology
Abstract
Recent advances in the field of stress have revealed that a molecular layer underlies the negative effects on brain function involving subcellular organelles in neurons. Our laboratory has greatly contributed to understand the role of the endoplasmic reticulum (ER) in cellular stress responses at the level of protein homeostasis (referred to as proteostasis) in the brain. X-box binding protein 1 (XBP1) is a fundamental transcription factor of the Unfolded Protein Response (UPR), operating as a master regulator of adaptation programs to attenuate ER stress. In this project, we plan to investigate the significance of the UPR in environmental stress induced behavioral alterations. Our main aim is to identify novel fundamental mechanisms underlying the resistance and vulnerability to adverse stress conditions and how they relate to proteostasis alterations. These ideas have not been explored yet in the liter
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 21, 2022
- Source ID
- FA95502110096XX0
Entities
People
- Claudio Hetz
Organizations
- Air Force Office of Scientific Research
- United States Air Force