Imaging-based analyses of subcellular neuronal energy metabolism, network activity, and synaptic function
Abstract
This proposal seeks partial funding for acquisition of essential accessories and upgrades to a laser scanning confocal microscope system to support ongoing research on low-energy bioinspired information processing. In the nervous systems of both simple and complex organisms, memory and other forms of information are stored as changes in the strength of synaptic connections, a form of neural plasticity. The central hypothesis of our multidisciplinary project is that such neural plasticity is tightly coupled to efficient energy metabolism. Our experiments seek to understand the molecular and cellular mechanisms that regulate this tight coupling in neurons, using simplified models that permit the direct imaging of the cellular fuel molecule ATP along with measures of synaptic strength. These experiments will provide essential quantitative data to help develop computational models that will inform the design of efficient information processing systems.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 07, 2023
- Source ID
- FA95502110135
Entities
People
- Shelley Halpain
Organizations
- Air Force Office of Scientific Research
- United States Air Force
- University of California, San Diego