CUSTOMIZED IMAGING SYSTEM WITH SPATIOTEMPORALLY ENCODED ELECTRIC FIELD MODULATION FOR PRECISE MANIPULATION OF NEURONAL DIFFERENTIATION AND NEUROPLASTICITY
Abstract
Cells respond to simple stimuli with complex responses through the biochemical, electrical, and mechanical signaling pathways. In our studies supported by the MURI project entitled Understanding and Controlling the Coupled Electrical, Chemical, and Mechanical Excitable Networks of Living Systems , we have investigated how these signaling pathways couple with each other and behave as excitable networks. We have pinpointed a new mechanism that specific electric field (EF) can electrostatically influence protein interactions at the cell membrane to trigger downstream signaling pathways. This enables manipulation of specific cell signaling pathways by an external field that can be precisely delivered in time and space. For this DURIP proposal, we seek support for constructing a customized imaging system, to further investigate how this mechanism can be used to precisely modulate critical signaling pathways for cell development and differentiation, so that we can control the fate and behavior of cells and networks.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 07, 2023
- Source ID
- FA95502110228
Entities
People
- Quan Qing
Organizations
- Air Force Office of Scientific Research
- Arizona State University
- United States Air Force