Lensless Computational Microendoscopy for Minimally-Invasive Hyperspectral Bio-Imaging
Abstract
We propose to develop ultra-small lensless microendoscopes for volumetric hyperspectral epifluorescence imaging. Hyperspectral fluorescence microscopy allows for information rich discrimination of structures and compounds within cells and tissues. For in-vivo studies minimal probe size is paramount when operating in sensitive regions such as the central nervous system. Conventional minimally-invasive solutions for freely moving in-vivo experiments leverage gradient refractive index (GRIN) lenses, which, while remarkably small for lenses, still dominate the invasiveness of such probes. Furthermore, small GRIN lenses are plagued by substantial chromatic aberration a significant impediment for hyperspectral imaging. Overcoming these limitations requires a fundamental change in imaging architecture as GRIN lens technology is mature and near its performance limits.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 07, 2023
- Source ID
- FA95502110372
Entities
People
- Mark A. Foster
Organizations
- Air Force Office of Scientific Research
- Johns Hopkins University
- United States Air Force