DURIP DISSECTING THE MOLECULAR PATHWAYS UNDERLYING THE HOMEOSTATIC INTERACTIONS BETWEEN METABOLISM AND CIRCADIAN RHYTHMS
Abstract
Circadian rhythms represent a natural cycling of our internal body states corresponding to the daily changes in the environment. It is also well known as our sleep-wake cycle, which is a nearly universal behavior in the animal kingdom. Misalignment of this cycle could have enormous impact on our health. In the literature, irregular sleep patterns and sleep loss have been shown to be one of the main factors causing metabolic syndrome, type II diabetes, and cardiovascular disease. It has been suggested that there is a tight connection between circadian rhythms and metabolism, but the underlying biological pathways between them remain elusive. It is the goal of our project to clarify these pathways and hence improve our fundamental understanding of the homeostatic interactions between metabolism and circadian rhythms.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 07, 2023
- Source ID
- FA95502210146
Entities
People
- Jen-yung Chen
Organizations
- Air Force Office of Scientific Research
- United States Air Force
- University of California, San Diego