DURIP SCANNING ION CONDUCTANCE MICROSCOPY-ENABLED ATOMIC FORCE MICROSCOPE FOR RESEARCH ON PEPTIDE NUCLEIC ACID-BASED NANOSTRUCTURES AT BIOTIC AND ABIOTIC INTERFACES
Abstract
Peptide Nucleic acids are synthetic DNA mimics that hold unique potential for use in nanostructured materials and machines. These information bearing polymers can bind to DNA and have distinct potential advantages over DNA that could lead to the manufacture of nanostructured materials and sensors that have long term stability at high temperatures, in organic solvents, and in the presence of enzymes that degrade DNA and proteins. The recent demonstration of formation of complex nanostructures from gamma modified NA oligomers that have enhanced binding affinit and versatile capacity for chemical functionalization. This advance expanded application for nucleic acid nanotechnology. Fundamental studies are needed to determine gammaPNA can replicate DNA as a nanomaterial.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 07, 2023
- Source ID
- FA95502210147
Entities
People
- Rebecca E Taylor
Organizations
- Air Force Office of Scientific Research
- Carnegie Mellon University
- United States Air Force