DURIP CUSTOMIZED SYSTEM UPGRADE TO IMAGE CELL SIGNALING IN VIVO AND EX VIVO SPATIOTEMPORALLY MODULATED WITH ELECTRIC FIELDS
Abstract
Our current MURI project entitled Understanding and Controlling the Coupled Electrical, Chemical, and Mechanical Excitable Networks of Living Systems has demonstrated that cells integrate electric signals-stimulation with biochemical signaling and biomechanical activities. Such integration of cell behavior reveals previously unknown potentials of controlling cells. For example, highly coordinated collective migration, collective activation of intracellular pathways, and cell differentiation, could be induced by delivery of electric fields in a spatiotemporally controlled manner. Some of these cellular behaviors have now been confirmed by our MURI team and other labs in vitro. One critical question remains to be answered- can such spatiotemporal regulation of cell signaling at the cell population level be achieved in vivo. This request for DURIP support for an imaging system upgrade will enable us to answer this question and update our parental MURI to allow in vivo control and visualization. Specifically, we seek support to upgrade a customized imaging system to determine how the novel control mechanisms using electric fields can be used to precisely modulate critical signaling pathways for cell signaling in organoids in vivo.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 07, 2023
- Source ID
- FA95502210149
Entities
People
- Min Zhao
Organizations
- Air Force Office of Scientific Research
- United States Air Force
- University of California, Davis