Voltage Regenerative Aptamer Sensor (VRAS) for Continuous Monitoring of Biomarkers
Abstract
The goal of this proposal is to investigate the fundamental properties of voltage-controlled aptamers as well as the role of two-dimensional (2D) nanomaterials on biological interfaces for applications such as regenerative biosensors. The fundamental results on the proposal will enable the development of sensor technology for wearable device applications that can continuously monitoring biological analytes of interest through sweat. A special aptamer selection scheme will be created to produce aptamers that are both highly sensitive and selective for target molecules of interest and, uniquely, release target molecules with an applied voltage. This type of voltage sensitive aptamers will allow the regeneration of aptamer sensors thus allowing continuous measurements. The aptamer will be functionalized onto electrodes with 2D materials. Various 2D materials will be studied to optimize the sensor performance. The sensor will then be integrated with a microfluidic sweat patch to form a wearable device.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 06, 2024
- Source ID
- FA95502310509
Entities
People
- Jeffrey Weldon
Organizations
- Air Force Office of Scientific Research
- United States Air Force
- University of Hawaiʻi System