Synthetic biological systems made using structural PNA nanotechnology
Abstract
Synthetic nanoscale biomaterials have potential toward establishing new functionalities in living cells, while providing fundamental insights into cellular pathways. While synthetic biology traditionally relies on genetic engineering to redesign or repurpose molecular sensors, machines and signaling networks in vitro, nucleic acid-based nanotechnologies also hold potential for modulating the behavior and capabilities of a wide variety of cellular systems. Specifically, autonomous nanomachines and nanorobots built from DNA have demonstrated increasing capabilities in the spaces of programmable motion, molecular assembly and cargo sorting. However, the operation of these systems is greatly limited, because low salt conditions and enzymatic digestion will damage and destroy DNA-based nanosystems. Chemical modification to improve stability is therefore necessary despite possible alterations in function.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 07, 2024
- Source ID
- FA95502310562
Entities
People
- Rebecca E Taylor
Organizations
- Air Force Office of Scientific Research
- Carnegie Mellon University
- United States Air Force