Preclinical Validation and Testing of Minimally Invasive Physiologic Monitoring Tools for Prolonged Critical Care Applications
Abstract
This proposal addresses the FY22 FOA-AFRL-AFOSR-2022-0008 MMPP call for proposals by a comprehensive multi-institutional collaboration involving the Autonomous Reanimation and Evacuation (AREVA) Research Program in San Antonio, TX as the technology validation institution and Beckman Laser Institute (BLI), University of California, Irvine (UCI) as developers of technologies applicable to management of casualties in the Prolonged Critical Care (PCC) environment. We pursue pragmatic testing of a new generation portable continuous lactate monitor (CLM); a field-deployable compact blood coagulation analyzer (cBCA); a portable optical coherence tomography system (F-OCT) and a method for assessment of histological markers of brain tissue injury with and without traumatic brain injury (TBI). Future Large-Scale Combat Operations (LSCO) will lead to high casualty-to-medic ratio and inability of evacuation for up to 72 hours putting the burden of diagnosis and prolonged austere management of casualties on medics. To address these dire challenges, we introduce currently unavailable medical technologies to assist in diagnosis and management of critically ill and test them in large animal combat-relevant polytrauma models carried out over 72 hours of continuous critical care. Objectives- 1) evaluate the CLM, cBCA and F-OCT in 72-hour large animal polytrauma models with and without TBI and aeromedical evacuation; 2) obtain temporal values from devices and correlate them with medical reference devices constituting standard of care in management; 3) investigate correlations between device values and physiologic and outcome data in animals with TBI, polytrauma, inhalation injury, burns, sepsis, single- and multiorgan failure; fluid resuscitation and over-resuscitation; metabolic derangements; 4) evaluate and quantify specificity and sensitivity of the device values in association with common clinical vital signs and outcome measures; 5) evaluate histological injury severity and tissue expression of TBI-specific injury severity markers in histological brain samples from animal with primary and secondary TBI in comparison with animals without specific TBI injuries.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 07, 2024
- Source ID
- FA95502310621
Entities
People
- Andriy I. Batchinsky
Organizations
- Air Force Office of Scientific Research
- Geneva Foundation
- United States Department of Defense