Understanding and tuning magnetism in correlated metals
Abstract
We are requesting funds to acquire a state-of-the-art Brillouin microscope that will allow us to investigate several cutting-edge research projects in the field of biophysics. Specifically, we plan to use the microscope to investigate (1) high-speed quantitative imaging of astrocyte-neuron networks, (2) neural cell mechanobiology on 3-D disordered nanomaterials, (3) targeted enzymeactivity imaging, and (4) dynamic tracking of astrocytes in astrocyte-neuron culture. The Brillouin microscope we are requesting is capable of measuring Brillouin frequency shifts with high sensitivity, typically on the order of 1 MHz or less. This level of sensitivity will enable us to detect subtle changes in the mechanical and optical properties of biological samples, such as small changes in stiffness or refractive index. Currently, we do not have access to a Brillouin microscope on our campus, making it difficult to investigate these important research questions. All of the projects we propose are in areas of interest to the Department of Defense (DoD). By acquiring the Brillouin microscope, we will be able to offer an orthogonal verification of the test results by other approaches originally proposed in the submitted and funded proposals, establish a completely new research capability, increase the resolution of the material characterization, enhance the quality of DoD-related research, and allow us to answer new questions that have arisen from ongoing research. Additionally, we have designed research-related training programs that utilize access to the Brillouin microscope and the data generated by the microscope to enhance the learning experience of our students.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Feb 05, 2025
- Source ID
- FA95502410048
Entities
People
- Yu He
Organizations
- Air Force Office of Scientific Research
- United States Air Force
- Yale University