Metabolic Signatures of Antimicrobial Resistance
Abstract
We propose herein to use our state-of-the-art analysis method known as “simultaneous multifiber headspace solid-phase microextraction (simulti-hSPME)” for the rapid and minimally invasive preparation of microbial metabolite fingerprints that uniquely identify biothreat-relevant microbes and differentiate between antibiotic susceptible and resistant strains. This research is of critical importance as it will help to generate a rapid diagnostic and quickly identify appropriate therapeutics effective against engineered or naturally occurring antibiotic resistant strains of select agent pathogens. This proposed study will involve both bacterial cultures and mouse models, and will be performed in our BSL3 facility. The project will include internships for competitively selected active military students currently enrolled in our Enlisted to Medical Degree Preparatory Program
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 13, 2016
- Source ID
- HDTRA11610040
Entities
People
- Robin Couch
Organizations
- Defense Threat Reduction Agency
- George Mason University