Microneedle extraction of dermal ISF for minimally invasive disease diagnostics
Abstract
Real-time monitoring of warfighter health status is vitally important to adjudicate medical decisions in the event of exposure to biological or chemical agents. This study will provide fundamental research results demonstrating the feasibility of using dermal interstitial fluid (ISF) to assess threat exposure. Dermal ISF, extracted from animal and human subjects, will be analyzed for a broad inventory of constituents that may be monitored as biomarkers of threat exposure. However, one of the major hurdles to the adoption of ISF as a diagnostic matrix is the lack of rapid, minimally invasive methods for its extraction. The proposed research will include the development of microneedle-based devices for painless extraction of dermal ISF. The multidisciplinary partnership of researchers at the University of Maine and the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) will enable a unique study of dermal ISF and blood of animal models pre- and post-biothreat exposure. Furthermore, the resulting microneedle patches will be prototypes for wearable diagnostics devices designed for warfighter use in field settings
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jul 10, 2017
- Source ID
- HDTRA11710021
Entities
People
- Rosemary L. Smith
Organizations
- Defense Threat Reduction Agency
- University of Maine