Surveillance and molecular epidemiology of especially dangerous respiratory viruses in commercial and backyard poultry and migratory waterfowl in India
Abstract
Emerging and re-emerging respiratory diseases in poultry, especially velogenic viscerotropic Newcastle disease (vvNDV) and highly pathogenic avian influenza (HPAI), present a major threat to animal and public health worldwide, especially in rapidly developing nations such as India. The core viral pathogens of human and animal concern involved in Respiratory Disease Complex of poultry have not been studied. To fill this knowledge gap, we propose to test three hypotheses. Hypothesis 1. The respiratory tract viromes from commercial and backyard flocks (herein referred to as domestic poultry) and waterfowl in Haryana, Odisha and Kerala are a potential source of especially dangerous pathogens (EDP); Hypothesis 2. Molecular genotyping approaches will identify host- and region-specific fingerprint profiles of select agents including vvNDV and HPAI; Hypothesis 3. Next generation sequencing will help identify nucleic acid signatures of novel / emerging viruses in domestic poultry and waterfowl. The overall goal of this project is to discover novel viruses and enable the development of genomics based strain-typing capability of EDP and emerging viral pathogens from avian sources in academic research settings in India. Molecular epidemiologic analysis and comparative metagenomics investigation of respiratory viromes of domestic poultry and migratory birds, using a comprehensive and statistically robust stratified random sampling approach, will provide a strong foundation for the development of evidence-based approaches for implementing sustainable measures to control EDP; and help generate data and tools, build sustainable capabilities, and enhance domestic and international academic partnerships critical to characterizing the zoonotic pathogens associated with domestic poultry and waterfowl in India.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 10, 2018
- Source ID
- HDTRA11710045
Entities
People
- Sagar M Goyal
Organizations
- Defense Threat Reduction Agency
- Regents of the University of Minnesota