Discovery and Manipulation of Biomolecular-Noble Gas Interactions
Abstract
This project constitutes a combined theoretical, synthetic, and bioanalytical effort that will elucidate the molecular mechanisms by which biological systems interact with noble gases. The knowledge gained from this effort will inform the design and development of next-generation noble gas collection/concentration, separation, and detection techniques that could be used, for example, to enable the detection of anomalous isotope distributions that are associated with nuclear arms activity. The expected outcomes of this project include direct and quantitative insights into biomolecular-noble gas binding and sequestration under physiologically relevant conditions. In the longer term, the results of this work will guide the design of devices the enable the efficient and effective detection of noble gases and provide a molecular and systems level understanding of noble gas mediated biochemistry.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jul 16, 2019
- Source ID
- HDTRA11810010
Entities
People
- Stephen L Craig
Organizations
- Defense Threat Reduction Agency
- Duke University