Mediated Electrochemical Probing: A New Approach to Reveal Global Redox Signatures of Exposure and State
Abstract
The goal of this project is to develop the fundamental underpinning science for a transformational approach to rapidly detect chemical information in deployable (or wearable) systems. This approach enlists the remarkable advances in information processing (not chemical analyses) to measure global patterns in chemical information. The approach is based on convenient electrochemical measurements of redox, and we propose to learn how these redox measurements can be tailored to access information from biology that reveals homeostasis and perturbations associated with exposure to stressors. The proposed work integrates research across the disciplines of electrochemistry, nanotechnology, materials and information sciences, and synthetic biology, and includes contributions from two academic labs from the University of Maryland, the Naval Research Lab and an Army Research Lab. The three specific aims include: (i) a signal processing aim that will determine how to probe for redox-based information from living systems by imposing redox inputs and detecting outputs through a combination of optical and electrical outputs; (ii) a synthetic biology aim that will reveal how biology detects redox-based information, processes this information through intracellular genetic circuits, and generates redox-based responses; and (iii) a materials science aim that will apply and develop thin hydrogel film technology to physically connect the biological information processing components (i.e., wild type cells or synbio constructs) to the electronics. We envision this work will be transformative by providing the enabling science to conveniently access and analyze global biological information (e.g., signature patterns) from remote, deployable and wearable sensing systems.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 01, 2019
- Source ID
- HDTRA11910021
Entities
People
- Gregory F Payne
Organizations
- Defense Threat Reduction Agency
- University of Maryland