AN INTEGRATED APPROACH TO IDENTIFY SHARED MOLECULAR PATHWAYS AND BROAD-SPECTRUM CWA TARGETS
Abstract
The military conflicts and terrorism often place our warfighters and first responders at risk for exposure to CWAs, which are difficult to treat due to their rapid onset of action that can have disabling or fatal effects. The most common routes of exposure include the skin, eyes and lung. While the specific mechanism(s) of toxicity of these agents on these sites are diverse, most are associated either directly or indirectly with severe inflammation and increased oxidative stress, leading to subsequent cell death, in the affected tissues. Improved understanding of the multiple global and regional processes involved in CWA associated inflammation and toxicity mechanisms is critical for accurate assessment and the development of effective medical countermeasures. The three key elements here are to select appropriate in vitro test systems and facilities, identify common molecular and cellular events, and apply cutting edge in silico and drug discovery tools to mine and shortlist potential drug candidates that can be validated in previously developed in vitro and physiologically relevant ex vivo test systems. These considerations and the substantial combined expertise of the proposing team fundamentally motivate this innovative effort. We have assembled a multi-institutional, multi-disciplinary team of scientists and engineers with expertise in all relevant areas of the proposed effort.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 04, 2021
- Source ID
- HDTRA12010009
Entities
People
- Narender Singh
Organizations
- CFD Research Corporation (United States)
- Defense Threat Reduction Agency