LncRNA regulation of intracellular parasitism by bacterial biothreat agents
Abstract
The long-term goal of this project is to identify and characterize long non-coding RNAs that are diagnostic for infection with the bacterial pathogen and biothreat agent Coxiella burnetii and to understand the molecular mechanism by which high-priority non-coding RNAs including long non-coding RNAs control Cb function. The specific objectives of this application are to test several working hypotheses, including discovery of lncRNA biomarkers of C. burnetii infection with limited cross-reactivity with other bacterial infections; identification of lncRNA biomarkers of Cb infection using two rodent models of infection; (3) control of Cb intracellular parasitism and/or disease caused by high priority lncRNAs. Important outcomes of this work include defining novel lncRNA biomarkers for Cb infection and illuminating functional roles for high priority lncRNAs in controlling the intracellular lifestyle and identifying mechanisms by which host lncRNA expression drive disease-associated inflammation linked with Q fever.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jun 14, 2022
- Source ID
- HDTRA12110002
Entities
People
- Paul Defigeiredo
Organizations
- Defense Threat Reduction Agency