Prototype Development of Broad-Spectrum Neuronal Nanosponges
Abstract
The objective of this proposal is to conduct prototype development of “neuronal nanosponge” as a broad-spectrum countermeasure platform technology to concurrently absorb and neutralize chemical and biological neurotoxins regardless of the toxins’ molecular structures. Based upon our successful prior studies on the development of human red blood cell (RBC) and white blood cell (WBC) nanosponges, herein, we will integrate neuronal cell membrane coating with three new cuttingedge strategies toward effective countermeasure of neurotoxins. Specifically, we will (i) introduce an oil core to the nanosponge formulation for dualmodal detoxification, (ii) combine toxin-degrading enzymes into nanosponge design for continuous detoxification, and (iii) genetically engineer the cell membrane to enhance the capacity and effectiveness of toxin neutralization. The work will also emphasize fundamental understandings on the structure-efficacy relationship in nanosponge design for better efficacy in vivo. Overall, successful completion of this project will lead to a new and powerful countermeasure platform effective against a broad range of neurotoxins, which undoubtedly will improve our ability to prevent and handle threat agents under various warfare-related scenarios.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jun 14, 2022
- Source ID
- HDTRA12110010
Entities
People
- Liangfang Zhang
Organizations
- Defense Threat Reduction Agency
- University of California, San Diego