Discovery of Bacteriophages that Mediate Antimicrobial Susceptibility Through Efflux Pump Dependent Infection
Abstract
Our main objective is to identify novel bacteriophages that can mediate antibiotic susceptibility conversion of antibiotic resistant Burkholderia pseudomallei due to efflux pump expression and to evaluate their utility in phage/antibiotic combination therapy. The premise is that efflux-pumps cause significant multidrug resistance and that phage targeting a crucial efflux pump component would kill via phage-mediated lysis, but that bacteria that develop resistance to these phage by mutation of the pump would become susceptible to the antibiotics these pumps confer resistance to.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jun 14, 2022
- Source ID
- HDTRA12110029
Entities
People
- Herbert Scheizer
Organizations
- Defense Threat Reduction Agency
- Northern Arizona University