Continuation of Host-Based Anti-Microbial Peptides (AMP) as Therapeutic Strategies for Alphavirus Infections
Abstract
This effort aims to explore a novel antimicrobial peptide (AMP) strategy from a basic research perspective to develop a medical countermeasure strategy for the treatment of New World alphavirus exposures. The application of AMPs as an antiviral strategy has been described for various viruses, including influenza and vaccinia viruses, is recognized. However, from the perspective of alphaviruses, this is an entirely novel approach. Additionally, AMPs are known to be immunomodulatory and offer unique opportunities to study host inflammatory events. This synthetic AMP strategy will focus on dual-function AMPs that can control viral load and decrease inflammatory response across the human BBB. ATCC will leverage cutting-edge model systems (organ- on-chip and organoids) to address pathology in a human tissue microenvironment setting.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Dec 19, 2022
- Source ID
- HDTRA12210003
Entities
People
- Aarthi Narayanan
Organizations
- American Type Culture Collection
- Defense Threat Reduction Agency