Identifying Host Pathways Important to Protective Immunity Against CCHFV
Abstract
Viral hemorrhagic fevers (VHF) are a group of viral diseases representing persistent threats to the national defense of the U.S. due to their lethality, potential for weaponization and endemic nature to areas of U.S. strategic interest. Of particular threat to our nation’s warfighters are Bioterrorism Category A VHFs such as the Ebola, Marburg, Lassa, Lujo, and Crimean-Congo Hemorrhagic fever virus (CCHFV). Currently, no CCHFV vaccine candidates have reached Phase I clinical trials curtailing the understanding of immunity build against CCHFV versus other VHFs. The objective of this work will be to define the correlates of protection associated with immunity against a broad-spectrum of CCHFV strains using a CCHFV viral replicon particle system (VRP).
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Dec 19, 2022
- Source ID
- HDTRA12210007
Entities
People
- Scott D Pegan
Organizations
- Defense Threat Reduction Agency
- University of California Regents