Host-based anti-microbial peptides as therapeutic strategies for alphavirus infections
Abstract
The effort proposed will develop novel synthetic antimicrobial peptides (AMPs) that can exert dual-functionality (antiviral and anti-inflammatory functions) in the context of alphavirus infections. Objectives are to Generate data on the applicability of membrane-permeable peptides that were generated based on machine learning (ML) approaches to reducing viral and inflammatory load in the context of the blood brain barrier (BBB). Generate data on the dual functionality of novel synthetic piscidin-based peptides to exert broad spectrum antiviral and anti-inflammatory activities in the context of acute viral infections. Generate data on the potential for combinatorial intervention strategies (small molecules and peptides) to elicit antiviral and anti-inflammatory outcomes. Generate data on delivery mechanisms to deliver a consistent payload of peptides in in vitro models to achieve extended dual-function outcomes. Generate proof of concept data on evaluation of in vivo efficacy of the synthetic AMPs either as single or as combinatorial approaches.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Dec 19, 2022
- Source ID
- HDTRA12210031
Entities
People
- Aarthi Narayanan
Organizations
- Defense Threat Reduction Agency
- George Mason University