Application of Multifunctional RNA Nanoparticle for Lung Cancer Therapy
Abstract
Lung cancer is the leading cause of cancer-related deaths in the U.S. Although chemotherapy has been used for lung cancer, its effectiveness and safety are not satisfactory. The Area of Emphasis the project addresses is to identify innovative strategies for the treatment of lung cancer. The objective of the project is to design multifunctional RNA nanoparticles for lung cancer therapy with a goal to identify innovative strategies for the treatment of lung cancer. RNA therapeutics can effectively knock-down the target gene expression involved in lung cancer development and hold an exciting promise for lung cancer treatment. However, the challenge of RNA therapeutics is their instability in biological fluids and low distribution in cancer cells. The application of RNA therapeutics is not successful because of their delivery problem. The proposed tumor-targeted multifunctional RNA-nanoparticles will improve their stability and pharmacokinetic profile and specifically target lung cancer cells to treat lung cancer. Moreover, multifunctional drugs like the proposed multifunctional RNA-NPs could be superior in therapeutic effect and possibly reduce unwanted effects in comparison to conventional chemotherapy with monospecific drugs or polypharmaceutic combinations of different agents. The proposed approach is significant and innovative because applications of multifunctional RNA-NP for lung cancer-targeted delivery and therapy have never been explored. It will create an entirely new avenue for tumor-targeted delivery and therapy. The project will eventually contribute to eradicating deaths from lung cancer to better the health and welfare of the military and the American public.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 04, 2024
- Source ID
- HT94252310014
Entities
People
- Jiukuan Hao
Organizations
- United States Army
- University of Houston