A CLOUD (CRISPR-Mediated Loci-Specific Unbiased Discovery) Atlas of Regulatory Binding Proteins for Driver Genes in Prostate Cancer Bone Metastases
Abstract
Prostate cancer (PCa) is the second most lethal cancer in U.S. men. One of the major reasons for PCa patient death is activation of the MYC gene. Unfortunately, we have not had any success yet in directly stopping MYC. Therefore, we are developing a tool to identify the proteins causing MYC activation so that scientists can develop effective methods to stop these proteins. The success of our proposal will address the overarching challenge to Define the biology of prostate cancer progression to lethal prostate cancer to reduce death. Our findings will help physicians and scientists understand the MYC activation better and develop drugs for PCa patients with MYC activation. The tool developed is also applicable in the studies of other genes and will open new avenues for discovery of key factors of PCa progression, metastasis, drug resistance, and tumor dormancy.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 04, 2024
- Source ID
- HT94252310015
Entities
People
- Shang Su
Organizations
- United States Army
- University of Toledo Health Science Campus