Core Transcription Factors in RMC
Abstract
Renal medullary carcinoma (RMC) is a rare kidney cancer that disproportionately affects adolescents and young adults of African ancestry. This cancer carries a poor prognosis and new therapies are needed. Our ability to analyze these samples has relied upon patient samples but these are very limited in quantity, limiting our ability to look at different aspects of RMC biology. We have several patient-developed cell lines for which we can now expand these cells for long periods of time. This now allows us to assess the changes at the epigenetic level, i.e., what regions of the DNA that are open or closed and allow for different genes to be turned on or off. This work is innovative in that we are using new techniques to study this very rare cancer. These techniques will let us better understand the epigenetics of RMC. Successful completion of this proposal will provide new insights into RMC biology and potentially lead to new therapeutic targets for this group of hard-to-treat kidney cancers.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 04, 2024
- Source ID
- HT94252310134
Entities
People
- Andrew L Hong
Organizations
- Emory University
- United States Army