Why Dietary Lipids Influence Intestinal Endotoxin Transport and Systemic Inflammation
Abstract
Peer Reviewed Medical Research Program (PRMRP) Portfolio Category: Nutrition and Metabolism Fiscal Year 2022 (FY22) PRMRP Topic Area: Nutrition Optimization FY22 PRMRP Strategic Goal: Foundational Studies – Understand correlations between nutrition and disease susceptibility (e.g., infectious, autoimmune, neurological, metabolic, cardiac) The diet that most people living in Western countries is high in saturated fats that come from animals and some vegetables. These fats are associated with an increased amount of heart disease, diabetes, high blood pressure, and other diseases common among the military, in Veterans, and in the developed world in general. The pathophysiology of many diseases that are common in the military and Veteran population such as diabetes, multiple sclerosis, chronic fatigue syndrome, fibromyalgia, arthritis, and asthma, is thought to be due in part to a leaky gut, in which toxic substances are thought to get into the body through gaps between the cells lining the intestine. Our laboratory has discovered that bacterial toxins that are believed to help cause many of these diseases enter the body by specific mechanisms that pass through, not around the cells lining the intestine. In the studies proposed in this grant application, my laboratory plans to clarify the specific ways by which these toxins are absorbed. We hope to translate these studies into the discovery of new treatments that will help tighten the leaky gut with the hope of preventing or treating many of these diseases mentioned before that commonly afflict Veterans and people living in the developed world who consume too much fat in their diet.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 04, 2024
- Source ID
- HT94252310180
Entities
People
- Jonathan Kaunitz
Organizations
- United States Army
- University of California, Los Angeles