Development of Immunotherapeutics for Heartland Virus
Abstract
Heartland virus is an emerging tick-born disease and is of significant concern to public health due to the severity of disease, as well as the geographic expansion of its insect vector. Infection with Heartland can result in a potentially fatal disease and frequently requires hospitalization. To date, little is known about the biology or ecology of Heartland virus, and there are no available treatments or vaccines. In addition, there are no commercially available diagnostic tests, making the study of this virus difficult. Antibody-based therapies have been shown to be beneficial for treatment of a wide variety of viral infections including COVID-19, MERS, Ebola, HIV, Influenza, and Zika. However, to date, none have been developed for Heartland virus. Here we aim to develop therapeutic antibodies to treat Heartland virus infection. These antibodies will also be useful for diagnostic testing and surveillance, as well as furthering our knowledge of this poorly understood virus.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 04, 2024
- Source ID
- HT94252310202
Entities
People
- Corey Balinsky
Organizations
- Naval Medical Research Center
- United States Army