Role of Uridine Phosphorylase 1 (UPP1) in Chromophobe Renal Cell Carcinoma
Abstract
Chromophobe renal cell carcinoma is a rare form of kidney cancer that can occur as a sporadic cancer or in patients with genetic syndromes such as Tuberous Sclerosis Complex and Birt-Hogg-Dubé. There are no proven therapies for patients with metastatic chromophobe renal cell carcinoma, most of whom will die of their disease, representing a significant unmet clinical need. The KCRP Focus Areas addressed by this proposal are: (1) Define the biology of rare kidney cancers and develop treatments to improve outcomes and reduce death. (2) Conduct basic biology research to better understand etiology and cancer progression, metastatic disease, refractory disease and therapeutic resistance, genetic and environmental risk factors and the prevention of kidney cancer. The proposed research focuses on Uridine Phosphorylase 1 (UPP1), a protein involved in key cellular metabolic processes that is upregulated in chromophobe renal cell carcinoma. We hypothesize that UPP1 regulates the proliferation and survival of chromophobe renal cell carcinoma cells by modulating their bioenergetic metabolism. The proposed studies may lead to a new area of research for chromophobe renal cell carcinoma: the identification of clinically relevant UPP1 inhibitors or inhibitors of other key enzymes in the UPP1 pathway. In summary, this project will uncover novel mechanisms in the pathogenesis of chromophobe renal cell carcinoma and provide insights into therapies for this rare kidney cancer.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 04, 2024
- Source ID
- HT94252310291
Entities
People
- Carmen Priolo
Organizations
- United States Army