Quantified Coronary Artery Plaque and Outcomes (QUIET): WARRIOR Ancillary Study
Abstract
The cardiovascular disease (CVD) burden, a major cause of mortality and morbidity among women, is increasing. Although emerging data document that most people with symptoms and or signs of chronic ischemic heart disease are women without obstructive coronary artery disease (INOCA), data are not available from large, randomized trials on an effective primary CVD prevention strategy for these women. The ongoing Department of Defense-funded WARRIOR trial is addressing this critical knowledge gap. However, the mechanisms responsible adverse outcomes in women with INOCA are unclear. The 2021 chest pain guidelines emphasize noninvasive testing utilizing coronary CTA, which provides the opportunity to evaluate mechanisms beyond presence/absence of obstructive plaque and calcification. Women participating in WARRIOR who underwent CCTA will provide an opportunity to better understand these mechanisms. This project is designed to take the coronary CT images from WARRIOR and perform more sophisticated measurements of the plaque in the coronary arteries to determine if this information can be used to determine who is at the highest risk to go on to have a cardiac events.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 04, 2024
- Source ID
- HT94252310659
Entities
People
- Carl J Pepine
Organizations
- United States Army
- University of Florida