Increase Clinical Trial Enrollment of Underrepresented Kidney Cancer Patients by Improving Access to Participation
Abstract
Scientific Objective and Rationale: In the world of cancer, clinical trials are the foundation for the approval of new drugs. Most patients who participate in cancer trials are non-Hispanic white, male, and younger than 65 years of age. This is no exception for trials specifically for kidney cancer. Kidney cancer is more common in men than women, and more prevalent in the African American, American Indian, and Alaska Native populations. However, we see fewer racial and ethnic minorities enrolled onto trials. Additionally, patients with limited financial resources are also less likely to participate in a trial for their cancer. It is well-studied that multiple barriers exist to clinical trial participation, especially among groups such as racial and ethnic minorities, women, older adults, and patients from lower-income households. For example, concerns about cost and limited or no education about clinical trials are two identified barriers that factor into a patient s decision not to enroll in a clinical trial. By offering educational programs and financial assistance, our goal is to increase enrollment of underrepresented patients on kidney cancer trials at Fox Chase Cancer Center (FCCC) and throughout Temple University Health System (TUHS). Applicability: Our project will help all kidney cancer patients at FCCC and throughout TUHS, who are hesitant to enroll in a clinical trial. The educational program will review topics such as the basics of a clinical trial, where a trial fits in a patient s cancer journey, and trials offered at FCCC and TUHS. To accommodate all patients, the program will be offered as a live in-person session and as a shortened video available for viewing during clinic visits. Information learned from the program will increase patient knowledge and improve preparation for decision making about clinical trials. A financial support plan will benefit patients who are worried about the indirect costs of participating in a clinical trial, such as food, lodging, and travel expenses. Clinical research nurses (CRNs) will advocate for patient assistance during the study start-up process and help patients apply for funding from non-profit organizations. The benefit of focused education on clinical trials allows the patient to play a more active role in their care and make an informed decision about participation. Clinical trial participation often times comes with additional indirect costs. Securing financial support for such costs will positively affect a patient’s decision to participate in a clinical trial. Potential risks exist with both goals of the project. The educational session may further increase patient concerns about participating in a clinical trial. Some patients may not qualify for financial assistance or may not receive adequate funds to cover costs associated with participation. Immediately after the education session or watching the video, a patient will have more knowledge about clinical trials and their kidney cancer. Patients can use this information at their next physician visit or when talking with friends and family about treatment options for themselves or others they may know with cancer. Patients can receive financial assistance for indirect costs from non-profit organizations after enrolling onto a trial. If a study offers a patient stipend or reimbursement, the patient typically receives reimbursement on a monthly basis. It is not well understood how race and ethnicity play a part in both the safety and the process by which a drug affects a patient s cancer. By including a broader population of kidney cancer patients in clinical trials, the results become more applicable to all kidney cancer patients. This will have a long-lasting impact on kidney cancer research and will positively affect patient outcomes.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 04, 2024
- Source ID
- HT94252310873
Entities
People
- Susan Rux
Organizations
- United States Army